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A series of diclofenac hydrazones was synthesized and the structure of the compounds was proved using different spectral methods such as infrared (IR), nuclear magnetic resonance (H-NMR) and high resolution mass spectroscopy (HR-MS). The biological evaluation, focused on in vitro antioxidant effects using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2’azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) free radicals scavenging assays was also performed. An improved antioxidant effect of the synthesized compounds compared to diclofenac was observed.

THE ANTIOXIDANT POTENTIAL EVALUATION OF DICLOFENAC DERIVATIVES WITH HYDRAZONES STRUCTURE