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Oxidative stress is induced by tobacco smoking and is also associated with anxiety and depression, two common psychiatric disorders, frequently associated with tobacco use. The aim of this study was to correlate tobacco use and mixed anxiousdepressive disorder (MADD) with oxidative stress markers useful in clinical practice. A study assessing uric acid, vitamin c and malondialdehyde, as oxidative stress markers, was conducted in 31 smokers versus non-smokers with MADD. Other useful parameters assessed were: serum cholesterol, triglycerides and creatinine. Smoking profile was quantified by the number of packs-years (PY) and Fagerström nicotine dependence score (FNDS) with exhaled carbon monoxide (CO) validation, while MADD was certified by the Hamilton Anxiety/Depression Scale (HAM-A/D.) Malondialdehyde (MDA) serum concentration was significantly increased in 73% of the smokers, while vitamin C was lower in 90% of both smoking and no smoking MADD patients. Lower concentrations of uric acid were found in smokers, suggesting a decreased endogenous production. Smoking amplifies oxidative stress described in psychiatric disorders. Monitoring biomarkers of both tobacco exposure and oxidative stress can improve disease management.

EVALUATION OF OXIDATIVE STRESS IN SMOKING AND NON-SMOKING PATIENTS DIAGNOSED WITH ANXIOUS-DEPRESSIVE DISORDER