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The aminomethylation of the well-known antioxidant butylated hydroxyanisole (BHA) was explored. A small library comprising eleven tertiary Mannich bases derived from BHA as substrate and piperidines, piperazines and other various secondary amines as amine reagents in aminomethylation has been synthesized and structurally characterized. The antimicrobial activity of these hitherto unknown derivatives of BHA against two bacterial strains (Escherichia coli and Staphylococcus aureus) and one fungal strain (Candida albicans) has been investigated. In a preliminary evaluation using the disk diffusion technique, none of the candidates exhibited significant antimicrobial activity at 100 mg/mL.

BRIEF EXAMINATION OF THE ANTIMICROBIAL ACTIVITY OF PHENOLIC MANNICH BASES DERIVED FROM BUTYLATED HYDROXYANISOLE