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Quantitative determination of andarine and ostarine in rat serum was achieved using two selective liquid chromatographymass spectrometry methods (LC-MS). After extracting the analytes and internal standards (ostarine and andarine) from the serum samples through a high throughput extraction method (protein precipitation), the samples were analysed by reverse phase liquid chromatography using as mobile phase a mixture of methanol and 10 mM ammonium formate solution (75:25, v/v). The analytes were detected following specific transitions in MS/MS mode of the QTOF mass spectrometer, after preionization by a negative electrospray ionization source (ESI-). Both methods were validated for a concentration range between 50 10000 ng/mL according to the current official guidelines with regards to carry-over, selectivity, linearity, withinand between-run accuracy, precision and can be applied to accurately measure andarine and ostarine levels in rat serum samples in order to design a pharmacokinetic study or for doping control purposes.

LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHODS FOR THE DETERMINATION OF ANDARINE AND OSTARINE IN RAT SERUM AFTER PROTEIN PRECIPITATION