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This study aimed to investigate the effects of different concentrations of zoledronic acid (ZA) on the proliferation of rat osteoblasts and the expression of insulin-like growth factor-1 (IGF-1) in vitro, and to provide a theoretical basis for its clinical use. Rat osteoblasts were divided in 5 groups: 1 control group cultured in normal culture medium and 4 experimental groups cultured in normal culture media with 10 mol/L, 10 mol/L, 10 mol/L, 10 mol/L ZA for 7 days. The proliferation of the primary cultured rat osteoblasts was evaluated by MTT (methyl thiazolyl tetrazolium) assay. The expression of IGF-1 was evaluated by ELISA method, and the ALP (alkaline phosphatase) was determined to detect the viability of basic phosphatase. ZA in concentrations above 10 mol/L inhibits the osteoblast proliferation. When the concentration of ZA was between 10 and 10 mol/L, no effect was observed on the cell proliferation. ZA inhibits osteoblasts ALP production at concentrations above10 mol/L. At concentrations between 10 and 10mol/L ZA have no effect on the expression of IGF-1. ZA is closely related to proliferation and IGF-1 expressions of rat osteoblasts.

EFFECTS OF ZOLEDRONIC ACID ON OSTEOBLAST PROLIFERATION AND IGF-1 EXPRESSIONS IN RATS IN VITRO