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The administration of immunosuppressive drugs affects the improvement of organ transplants. However, they can have a double effect, because it is well established that immunosuppressive drugs may result in nephrotoxicity related to the development of chronic graft dysfunction and acute rejection. The aim of the study was to determine a correlation between the therapeutic effect of immunosuppressants and IL-6 -174G > C polymorphism in patients after renal transplantation. A total of 185 patients receiving cyclosporine (CsA) were involved. The genotype frequencies were determined using the real-time polimerase chain reaction (PCR) method. The highest doses of cyclosporine were used for carriers of the GG genotype (GG: 196.00 mg vs GC: 169.70 mg and CC: 170.00 mg, p = 0.77). No such correlations were found for the determined blood concentration of CsA, because carriers of the CC genotype had slightly lower mean drug concentration in the blood as compared to the individuals with the GG and GC genotypes (CC: 112.41 ± 6.95 ng/mL vs GG: 119.08 ± 51.31 ng/mL and GC: 135.24 ± 28.68 ng/mL, p = 0.78). In addition, a comparison of the IL-6 genetic variants and the biochemical parameters found no potential risk for transplant rejection. However, the results obtained for creatinine suggest that patients with the CC genotype and receiving CsA may be at high risk of kidney graft rejection. These results indicate that IL-6 polymorphism may influence the dosage of immunosuppressive drugs in patients after transplantation as far as the individualization of therapy is concerned.

EFFECT OF INTERLEUKIN-6 POLYMORPHISM ON FUNCTION OF THE RENAL ALLOGRAFT FUNTION AND EFFICACY OF IMMUNOSUPPRESSIVE THERAPY