English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Antidepressants and antipsychotics are drugs used in the treatment of neuropsychiatric disorders, but because they have side effects on new-borns their use is not recommended during pregnancy. Natural compounds represent an innovative opportunity for the management of depression, but the molecular mechanisms on brain membrane receptors are unknown. Our aims are to predict the binding affinities of melatonin, resveratrol, linalool and linalyl acetate at SERT (serotonin transporter), deeply involved in neuropsychiatric disorders mechanisms, their drug likeness, pharmacokinetics features and the transfer index (TI) through placenta by using QSAR (Quantitative Structure-Activity Relationship) and in silico ADMET (Absorption Distribution Metabolism Excretion Toxicity) techniques. Our study concluded that natural compounds represent promising drug candidates in the treatment of depression.

COMPUTATIONAL APPROACHES OF NEW PERSPECTIVES IN THE TREATMENT OF DEPRESSION DURING PREGNANCY