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Intravenous plasma concentration-time curve and AUC of pirarubicin, which is metabolized mainly in the liver, infused in the hepatic artery with or without hyperthermia is compared . One patient with hepatocellular carcinoma and 4 cases with metastatic liver cancer were enrolled. Pirarubicin (THP-ADR) (15mg/m2) was infused in proper hepatic artery in 20 minutes from implanted catheter. Intravenous plasma concentration of the drug was measured immediately after injection, 0.5, 1, 3 and 6 hours after injection respectively. Three weeks later, the same amount of the drug was injected to the same patient concomitantly with hyperthermic treatment of the liver using Thermotron RF8 and the drug concentration was measured. Changes of WBC, platelets counts, total bilirubin and AST (GOT) after pirarubicin injection with or without hyperthermia were also compared. Mean value of AUC (HR •~ ƒÊg/ml) of the injected pirarubicin without and with hyperthermia were 0.068 +/0.022 and 0.062 +/0.023 respectively. No significant difference of AUC between hepatic injection alone and injection during hyperthermia was seen by paired t-test (p = 0.563). No significant difference was seen in WBC, platelets counts, total bilirubin and AST between pirarubicin injection with and without hyperthermia. It was suggested that toxicity of pirarubicin injected in hepatic artery would not increase even if combined with hyperthemic treatment of the liver. Introduction Metastatic liver cancer or advanced hepatocellular carcinoma were hardly curable disease. To treat such patients, intra-arterial infusion of anti-neoplastic agents is attempted . Compared to conventional intravenous administration, hepatic intra-arterial infusion therapy of anti-neoplastic agent, pirarubicin Received 3 February 2004, Accepted 6 July 2004 . *Corresponding author, Phone : +81-739-26-7050 ; Fax : +81-739-24-2055 ; E-mail : k-tsuji@mwn. hosp. go. jp

nihon haipāsāmia gakkaishi/nihon haipasamia gakkaishi

Effect of Hepatic Hyperthermia on Plasma Concentration-Time Curve of Pirarubicin after Hepatic Arterial Infusion in Patients with Primary or Secondary Liver Cancer