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12 www.wjir.org AbstractConcentrations of antibiotics below the minimum inhibitory concentration encourages the overgrowth of organisms and the reason they survive is because they are resistant to the drugs prescribed and so able to proliferate quickly, assisted by the sudden access to nutrients and space.This palpable reality is a potential threat to the future of health care delivery and forms a basic consideration in the present study. The influence of sub inhibitory doses of Flucloxacillin or Clindamycin and plasma on Staphylococcus aureus clinical isolate was investigated using standard methods. The immune system is represented with fresh, preserved human plasma freeonly of erythrocytes. The study showed that human plasma can slow growth of invading organisms, even though this will have to be considered alongside the number of the invading organism and time it takes for antibodies to be produced. The exposure of the test organism to sub-minimum inhibitory concentrations of flucloxacillin and clindamycin showed clear resistance against the two test antimicrobial agents but significantly against the narrow spectrum flucloxacillin.This further illustrates effect ofadministering sub-therapeutic concentrations of antibiotics and the consequences ofthe invading organism acquiring resistance.Itis hoped that this research will lead to a reexamination of how antibiotics areadministered for management of patients suffering from recurrent S. aureus related diseases.

Effect of Sub-Inhibitory Concentrations of Flucloxacillin or Clindamycin and Plasma on Staphylococcus aureus Clinical Isolate