NbCl5-AgClO4 AS AN EFFECTIVE, SYNERGETIC CATALYTIC SYSTEM FOR THE SYNTHESIS OF FULLY SUBSTITUTED PYRAZOLES

The synergetic effect of the combined catalytic system of NbCl5-AgClO4 has been observed for the one-pot synthesis of fully substituted pyrazoles through the pseudo-five-component reaction between aldehydes, phenyl hydrazine and ethyl acetoacetate at room temperature in dichloromethane. This approach exploited the synthetic potential, synergetic effect of the combined catalytic system over the constituent parts and offered many advantages such as excellent yields, shorter reaction times, easier isolation of products, and environmentally benign reaction conditions. A diverse range of aldehydes smoothly underwent the reaction under the optimized conditions to offer the corresponding products.