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The mononuclear complex of VO(II) with ethyl-4-aminobenzoate (4-EAB) and oxalate ion (OX) have been synthesized and characterized based on physico-chemical, spectral and bio-potential activities. The conductance nature of the complex was confirmed by molar conductance of 10 M solution. The mononuclear nature and formula of the complex were confirmed by its metal estimation and elemental analysis studies. Probable geometry and ligating ability were also confirmed by its IR, electronic spectra and magnetic moment. The metal coordinated atom ability of the complex was confirmed by its Far-IR spectral study. The bio-potential activities of the complex were carried out Agar well diffusion method and compared with those for the ligand as well as standards (Chloramphenicol). The in-vitro antibacterial activity of VO(II) complex was screened for gram-positive S.aureus. The DNA cleavage of super coiled pBR322 DNA by metal complex also carried out and find out the cleavage nature of ligand and complex. The in-vitro anticancer activity of the ligand and VO(II) complex was carried out by using a human breast cancer cell line (Michigan Cancer Foundation-7 (MCF-7). Cytotoxicity assay, inhibition Concentration (IC50) and absorbance at 570 nm were evaluated by the MTT reduction assay and UVSpectrophotometer.

IN-VITRO ANTICANCER ACTIVITY AND DNA CLEVAGE OF BIOLOGICALLY ACTIVE VO(II) COMPLEX WITH ETHYL-4-AMINOBENZOATE AND OXALATE ION