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A new RP-HPLC method was developed for the simultaneous estimation of Escitalopram and L-methyl folate in bulk and pharmaceutical dosage forms. The chromatographic separation was carried out on DSC18column(4.6x250mm,5μparticlesize) with an isocratic mobile phase composed of an orthophosphoric acid buffer, Acetonitrile, (45:55v/v) at a flow rate of 1mL/min. The temperature of the column was maintained at30°C and PDA detector at 215 nm was used during separation. The parameters like system suitability, specificity, linearity, precision, accuracy, LOD, LOQ and robustness were validated as stated in the ICH guidelines. The retention times for Escitalopram and L-methyl folate were2.158minand 3.899minrespectively. The % recoveries of Escitalopram and L-methyl folate were100.42 % and 100.14% respectively. The% RSD for assay of tablets was found to be less than 2%. Forced degradation studies were also noted. The proposed method was accurate, sensitive and precise. Hence the method can be used for quality control of tablets containing both drugs escitalopram and L-methyl folate in quality control laboratories and pharmaceutical industries.

rasayan journal of chemistry/rasayan journal of chemistry

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ESCITALOPRAM AND L-METHYLFOLATE IN BULK AND TABLET DOSAGE FORM