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It has been ascertained that the extract of sirih hijau (Piper betle Linn) possesses some bioactivities, particularly its ability to inhibit the α-glucosidase enzyme. However, certain compounds contained in the betel leaf extract which can act as glucosidase enzyme inhibitors are not widely known. In this research, betel leaves were air-dried and mashed into dry powder. The dry powder was macerated in methanol and filtered, and the isolate results were partitioned successively with n-hexane and ethyl acetate. The isolation of the compound was done by column chromatography using silica gel 60 mesh as the stationary phase and a mixture of chloroform-methanol (9:1, v/v; and 8:2, v/v). Four fractions were obtained with various combinations of solvents, one of which was a mixture of benzene-ethyl acetate (7:3, v/v) which resulted in a pure isolate. The structure of the isolated molecule was determined by using the spectroscopy procedure based on ultraviolet-visible, infra-red, and nuclear magnetic resonances spectroscopy. It gave rise to α-glucosidase inhibitory potential evaluated in vitro based on UV-Vis spectrometry. An isolated compound, identified as 2-hydroxychavicol, was successfully isolated from Piper betel leaves. The compound has an α-glucosidase inhibitory potential with IC50 value of 72,87 ppm.

ISOLATION AND IDENTIFICATION OF α-GLUCOSIDASE INHIBITORY COMPOUNDS FROM ETHYL ACETATEEXTRACT OF Sirih Hijau (Piper betle L.)