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Quercetin has been used in combination with other nutraceutical components to improve renal function. Its development as an active pharmaceutical ingredient, however, is limited by poor aqueous solubility and low rate of dissolution.Solid dispersion of quercetin with polyvinylpyrrolidoneK30 increased its solubility 13.24 times and the amount dissolved (95.12 + 1.83) % compared to pure quercetin. This study aimed to determine the lethal dose (LD50) of the solid dispersion in mice. The animals were divided into 5 groups, a control group (G1), and treatment groups given quercetin solid dispersions at the doses of 2 (G2), 4(G3), 8(G4), and 16 g/kg (G5), respectively. The observation was conducted for 24 hours, and every day for 14 days if no death was found. Results showed that there was no animal found dead during the first 24 hours. The treatment did not influence the average bodyweight significantly (p>0.05), but it significantly influenced the feeding behavior (p<0.05). The organ weight ratios of heart, liver and renal were not influenced significantly (p>0.05), despite there was a decrease in renal function at doses of 8 and 16 g/kg. In conclusion, the solid dispersion was practically non-toxic with the LD50> 16 g/kg.

A STUDY ON THE ACUTE TOXICITY OF QUERCETIN SOLID DISPERSION AS A POTENTIAL NEPHRON-PROTECTOR