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The aim of the present study was to evaluate the hepatoprotective potential of Centella asiatica L. against paracetamol-induced hepatotoxicity in experimental rats. Liver toxicity was induced by paracetamol drug at a dose level of 3g/kg each, p.o for 7th and 14th days. About 50% ethanol extract of Centella asiatica L. (100 and 200 mg/kg) was administered orally once everyday up to 14 days. The hepatoprotective activity was assessed using different biochemical markers SGPT, SGOT, ALP, bilirubin, total protein and LDH. Meanwhile, in vivo antioxidant activities as SOD, CAT, GSH and, LPO were measured in liver homogenate and histological examinations were carried out to assess the hepato-protective activity. The values were subjected to one-way analysis of variance (ANOVA) followed by Tukey multiple compare test. Results were considered statistically significant at the level of P < 0.001. Obtained results demonstrated that the treatment with Centella asiatica L. (C. asiatica) significantly prevented the drug-induced increase in serum levels of hepatic enzymes. Furthermore, C. asiatica significantly reduced the lipid peroxidation in the liver tissue and restored the activities of defense antioxidant enzymes SOD, CAT and GSH towards normal. Histopathology of liver tissue showed that C. asiatica attenuated the hepatocellular necrosis, regeneration and repair of cells towards normal. The results of this study strongly indicate the protective effect of C. asiatica against paracetamol liver injury which may be attributed to its hepatoprotective activity, and there by scientifically support its traditional use.

Hepatoprotective activity of Centella asiatica linn. against paracetamol induced liver damage in experimental animals