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Endophytic fungi are most commonly found in plants. They are present inside the plants and supporting plants to survive and produce many bioactive metabolites. Lovastatin is one of the secondary metabolites produced by the endophytic fungi. It is used in the treatment of high blood cholesterol and reduces the risk of cardiovascular diseases. Objective: Screening and Production of Lovastatin Producing Endophytic Fungus from Phyllanthus reticulatus using Oyster Mushroom Extract. Methods: In our study, we have isolated endophytic fungi from the leaves and stem of phyllanthus reticulatus. Biodiversity of the endophytic fungi was calculated. Neurospora crassa bioassay was performed to identify the best producer of lovastatin. Their Lovastatin production potential was investigated with two different mediums such as potato dextrose and the mushroom extract. After completion of the fermentation process, the broth was extracted by a simple distillation method and then analyzed for the presence of Lovastatin using UV-Visible spectrophotometer and HPLC. Results: One of the positive and dominant endophytic fungi, Curvularia sp was isolated and chosen for this study. Its Lovastatin producing potential in PDA and mushroom extract medium was investigated and confirmed. Conclusion: Curvularia sp was identified as a better Lovastatin producer when compared to other endophytic fungi isolated from Phyllanthus reticulatus. From the results of the UV and HPLC, the presence of lovastatin is confirmed.