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Oral squamous cell carcinoma (OSCC) is the most common type of tumor in the oral cavity. OSCC is frequently associated with poor prognosis.1,2 Many factors have been reported for the cause of OSCC are nutritional deficiency, habit history like tobacco, pan, gutka, and virus also play a role in cancer like human papillomaviruses (HPV).3,4 It is known that molecular alterations, microenvironment changes are seen.5,6 The premalignant lesions with malignant transformation show stromal alterations important for tumor progression7 Lesions like leukoplakia and oral epithelial dysplasia are reported with malignant transformation.6,8,9,10 Even with numerous recent advances in OSCC, it is still a challenge. The complex balance of the oral cavity also plays an important role, like saliva can be used as a diagnostic tool.11 With various other diagnostic methods still in some regions, the prevalence of oral cancer is higher around 45% in India and 10% in Pakistan.12 Multiple primary tumors in the head and neck region show more recurrence even after complete excision, where the concept of field cancerization was explained.13,14 . ABSTRACT

Correlation of Site of Occurrence of Oral Squamous Cell Carcinoma and Level of Lymph Node Metastasis