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The problem of studying the pathogenesis and treatment of wounds and wound infections with diabetes mellitus is one of the most important sections of scientific and practical medicine. Issues of treating wounds and wound infections are sufficiently reflected in the scientific works of many scientists.1,2 However, the course of purulent wounds against the background of diabetes and the accompanying thyrotoxicosis is one of the urgent tasks of modern purulent surgery. In recent years, cases of combined pathology of thyrotoxicosis with diabetes have become more frequent in patients with purulent surgical diseases.3 In this regard, the course of the wound process in this category of patients is important. The complex pathogenetic mechanism for the development of diabetes is systemic. On the one hand, microcirculatory disorders, ischemia, tissue hypoxia, the development of oxidative disorders in cells with diabetes mellitus.3,4 and on the other hand, hemodynamic disorders, inhibition of the immune system, and metabolic disorders in thyrotoxicosis negatively affect the outcome of purulent surgical diseases.5-7 Decreased resistance to infection and the frequent occurrence of purulent-inflammatory diseases in patients with diabetes are caused by impaired immunological and plastic processes in the tissues. This is based on insulin deficiency that has an active effect on all metabolic processes.2,4,8 All this leads to a slowdown in regeneration and reparative processes.

Protein Metabolism Disorders in Patients with Purulent Wounds with Thyrotoxicosis Against Diabetes Mellitus