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Cerebral edema is a condition due to the excess water in the intra-and/ or extracellular space of the brain.1 It is a response to brain injury that occurs in up to 50% of patients with traumatic brain injury.2,3 Abnormal fluid accumulation causes increased brain volume and increased intracranial pressure (ICP) due to a closed rigid skull. Increased ICP in the brain induces adverse conditions including reduced cerebral blood flow, hypoxia, and suppression of brain tissue and hernias. This causes irreversible impairment of nerve function, and at worst can lead to death. Thus, the severity of cerebral edema correlates with increased ICP. Cerebral edema has been observed in capital trauma, cerebral ischemia, bleeding, liver failure, and delayed recovery after brain damage.4

The Correlation of Serum S100B Levels to Cerebral Edema in Patients with Mild and Moderate Brain Injury