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Introduction: Gallbladder cancer (GBC) is the most common cancer of the biliary tract. In north India, it is the commonest gastrointestinal cancer in females and 3rd most common cause of cancer deaths in women.1 Most patients with GBC have advanced disease at presentation and thus 5yr survival rate is <5% in most series. Prognosis and survival related to the stage. Thus, early and accurate diagnosis is important to prevent delayed treatment. GBC presenting as wall thickening is seen in 20-30% of cases.2 Wall thickening could also be seen in certain benign conditions e.g. xanthogranulomatous cholecystitis, which could be easily managed by laparoscopic cholecystectomy.3 most of the time it could be difficult to differentiate from malignancy. Transabdominal sonography (USG) is the first imaging examination performed because of its low cost, non-invasiveness and widespread availability. Although USG has a high sensitivity for detecting tumours at advanced stages, however, have some limitations.4 CT and MRI have been widely used for the diagnostic dilemma. A contrast-enhanced computed tomography (CECT) scan is the recommended diagnostic modality following suspicion of GBC on USG. But the value of CT in differentiating between benign and malignant GB wall thickening is limited.5 There for there is a need for better or an additional imaging modality.6 Magnetic resonance imaging (MRI) has been introduced to characterize GBC. GBC is typically T1 . ABSTRACT

Role of Diffusion-Weighted MRI Imaging in Diagnosing Malignancy in Patients with Thick Wall Gallbladder