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Background: Despite of tuberculosis control programme and anti-tuberculosis drugs, tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB) is a serious public health issues worldwide. Rapid laboratory detection of M. tuberculosis is needed for the early diagnosis and treatment of TB and MDR TB.Recently GeneXpert MTB/RIF system is a new molecular technique introduce for early detection of M. tuberculosis. Aim: To find out prevalence of MTB and MDR TB by using GeneXpert MTB/RIF system and also find out associated risk factor with MTB. Material and Method: Total 250 patients with suspected MDR pulmonary tuberculosis visited to TB & Chest OPD over a period of 2 years were included in study. Sputum sample was taken from each patient and tested by the GeneXpert MTB/RIF assay according to standard protocol. Result: Among 250 patients, 159 (63.6%) patients were detected as MTB positive. Out of 159 MTB patients 15 (9.43%) were detected with MDR. Maximum number of MTB was detected in patients from lower socioeconomic status. Out of 159 MTB patients, 25.15 % had showed HIV and TB coinfection. Among 15 MDR patients, 7(46.67%) were found to be defaulter,1(6.66%) due to failure & 7 (46.67%) were newly diagnose. out of 159 MTB detected patients 93 (58.49%) were cured,41 (25.79%)were died & 25 (15.72%) were still on treatment. Conclusion: Newer rapid molecular diagnostic techniques like GeneXpert will help to diagnose tuberculosis & multidrug resistant tuberculosis early so prompt treatment can be initiated for better outcome.

international journal of current research and review

Prevalence of Mycobacterium Tuberculosis and Multidrug Resistance Tuberculosis by Using GeneXpert MTB/ RIF System at a Tertiary Care Center in Maharashtra