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Hepatic cystathionine beta-synthase activity was increased in rats fed a high-protein diet for three or five days as compared to rats given laboratory chow (day 0). In the low-protein diet group, the enzyme activity decreased after both feeding periods. Similar changes in the cystathionine beta-synthase mRNA levels were observed in the rats fed these diets. The changes in cystathionine beta-synthase activity caused by alteration of the dietary protein content were mainly due to changes in the mRNA levels.

The Effect of a High-Protein Diet on Cystathionine .BETA.-Synthase Activity and Its Transcript Levels in Rat Liver.