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Susceptibility to some antagonists of vitamin B6 was studied in frogs and cockroaches after operational intervention in their central nervous systems, and also in the intack frogs and cockroaches. Thiosemicarbazide, semicarbazide, isoniazide and penicillamine induced wild jumping behavior, and tonic or clonic convulsions in frogs, when the nervous parts posterior to the optic lobe inclusive remained intact. In frog, in which the nervous parts anterior to the diencephalon inclusive had been removed, no convulsions were induced by castrix or 4-deoxypyridoxine in large doses. In cockroaches excessive fluttering of wings and convulsions upon administration of thiosemicarbazide following severance of the central nerve cord between the subesophageal and prothoracic ganglions were induced. Castrix was not a convulsant in the intact frogs and cockroaches.

Action site of antagonists of vitamin B6 in the central nervous system of the frogs and cockroaches.