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Nigrostriatal dopaminergic function in patients with Parkinson disease can be assessed using 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropan dopamine transporter ( 123 I-FP-CIT) SPECT, and a good correlation has been demonstrated between nigral status on SWI and dopaminergic denervation on 123 I-FP-CIT SPECT. Here, we aim to correlate quantified dopamine transporter attenuation on 123 I-FP-CIT SPECT with nigrosome-1 status using susceptibility map-weighted imaging (SMWI).

Determining the Degree of Dopaminergic Denervation Based on the Loss of Nigral Hyperintensity on SMWI in Parkinsonism