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In the article “Multi-parameter MR Imaging in the 6-OPRI Variant of Inherited Prion Disease,” featured in this issue, De Vita et al[1][1] evaluate a particular mutation of human prion disease, thereby making an essential contribution to our understanding of the clinical and radiologic spectrum

Imaging of the6-OPRIMutation Prion Disease: An Entity Distinct from Typical Creutzfeldt-Jakob Disease?