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Cerebral perfusion and O(2) metabolism are affected by physiologic age-related changes. High-resolution motion-corrected quantitative T2'-imaging and PASL were used to evaluate differences in deoxygenated hemoglobin and CBF of the gray matter between young and elderly healthy subjects. Further combined T2'-imaging and PASL were investigated breathing room air and 100% O(2) to evaluate age-related changes in cerebral autoregulation.

Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging