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GM volume, WMH volume, and FA are each associated with cognition; however, few studies have detected whether these 3 different types of MR imaging measurements exert independent or additive effects on cognitive performance. To detect their extent of contribution to cognitive performance, we explored the independent and additive contributions of GM atrophy, white matter injury, and white matter integrity to cognition in elderly patients.

The Contributions of MRI-Based Measures of Gray Matter, White Matter Hyperintensity, and White Matter Integrity to Late-Life Cognition