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I read with great interest the retrospective study by Hom et al,[1][1] in which a model combining clinical metrics with blood-brain barrier (BBB) permeability data from dynamic CT was presented to predict symptomatic hemorrhagic transformation (HT) and malignant edema in acute ischemic stroke. The

Predicting Transformation to Type 2 Parenchymal Hematoma in Acute Ischemic Stroke by CT Permeability Imaging