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INVEST is a recently published double-blind placebo controlled randomized trial that demonstrated similar improvements in pain between blinded vertebroplasty and sham-vertebroplasty groups. LABEL is a trial determining the efficacy of pain relief of an injection of lidocaine and bupivacaine at the site of painful osteoporotic vertebral compression fractures in unblinded patients. We compared outcomes from the unblinded LABEL trial with those of blinded control patients from the lead site of the INVEST, exploring the role of blinding on the benefit of local anesthesia infusion for painful vertebral compression fractures.

american journal of neuroradiology

Local Anesthesia with Bupivacaine and Lidocaine for Vertebral Fracture Trial (LABEL): A Report of Outcomes and Comparison with the Investigational Vertebroplasty Efficacy and Safety Trial (INVEST)