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Several morphometric MR imaging studies have investigated age- and sex-related cerebral volume changes in healthy human brains, most often by using samples spanning several decades of life and linear correlation methods. This study aimed to map the normal pattern of regional age-related volumetric reductions specifically in the elderly population.

Brain Structural Variability due to Aging and Gender in Cognitively Healthy Elders: Results from the São Paulo Ageing and Health Study