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The callosal disconnectivity theory was previously proposed to explain the pathophysiology of schizophrenia. The goal of this study was to investigate the metabolic integrity of the corpus callosum in patients with schizophrenia by proton MR spectroscopy.

Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection