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It is known that the skeleton tissue performs systemic energy metabolism regulation through the release decarboxylated fracture of osteocalcin. The aim of this study was to analyze the correlation between rs1800247 polymorphic variant of BGLAP gene and the development of type 2 diabetes mellitus in Ukrainian smokers and non-smoking individuals. There was no significant differences in alleles and genotypes distributions in both smoking subgroup (χ2 = 0,062; Р = 0,803 and χ2 = 0,222; Р = 0,895 respectively) and non-smoking (χ2 = 1,382; Р = 0,24 and χ2 = 3,314; Р = 0,191 respectively) groups. Using logistic regression method it was established the lack of association between rs1800247-polymorphic locus of BGLAP and type 2 diabetes mellitus in crude models and after the adjustment for age, sex, mass body index and the presence of arterial hypertension (Р ˃ 0,05). No statistically significant differences were found out between clinical and laboratory values among diabetic patients stratified by genotype in one-way analysis of variance (Р ˃0,05). It suggests the conclusion that rs1800247-polymorphism is not associated with type 2 diabetes mellitus development in both smokers and  non-smoking individuals.

ANALYSIS OF CORRELATION BETWEEN BGLAP RS1800247 POLYMORPHISM AND DEVELOPMENT OF TYPE 2 DIABETES MELLITUS IN SMOKERS AND NON-SMOKING INDIVIDUALS