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Pharmacokinetic models utilize mathematical terms to do pharmacokinetic analysis. Pharmacokinetic analysis of drug is defined as an experimental method to find drug exposure once administered or how does drug behave inside the body. Pharmacokinetic parameters determined include drug absorption, distribution, metabolism and elimination after its administration. These two types of models are used compartment and non -compartment models. A compartment is defined as space inside the body that a drug occupies upon its administration. When there is linear kinetics, it is desirable to use a simple non-compartment model with lesser assumptions, while when a compound follows non-linear kinetic, it is preferred to use a compartment model. Noncompartment model utilizes concentration-time data to predict C max, t max, AUC and AUMC for the administered compound. AUC and AUMC can be calculated using the trapezoidal rule. Pharmacokinetic parameters can also be predicted using statistical moment theory.

Determination of Pharmacokinetic Parameters by the Application of Noncompartmental Analysis