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Amburana is one of several plants popularly used in Brazil for medicinal purposes. Studies of these plant species are of utmost importance to ensure safety in their use by the population. The use of tests such as the Allium cepa bioindicator is one of the first and most reliable screening methods. The present work aims to evaluate the implication of exposure to herbal medicine and different concentrations of aqueous extract of Amburana cearensis seeds on cell proliferation in bioindicator. Allium cepa test system was used as bioindicator and 6 treatments were produced: T1 control (distilled water); T2, T3, and T4 aqueous extracts of A. cearensis (10g.L-1, 20g.L-1, and 30g.L-1, respectively); T5 exposure to amburana herbal medicine; and T6, 15% glyphosate exposure, each treatment had 4 repetitions, exposing the roots of the onion bulbs to the treatments for 24 hours. The slides were prepared and made, which were observed under the optical microscope with 40X magnification and subsequent analysis of the Mitotic Index. Data were analyzed by analysis of variance and Tukey test at 5% probability. The three different concentrations of Amburana cearensis aqueous extract (10 gL-1, 20 gL-1 and 30 gL1) led to a sharp reduction in Mitotic Index in relation to the control, equaling the positive control (15% glyphosate). while amburan-based herbal medicine produced a reduction in the mitotic index. Thus, the treatments tested affected cell proliferation in A. cepa showing cytotoxic effect.

EXPOSIÇÃO DE BIOINDICADOR A EXTRATOS AQUOSOS E A FITOTERÁPICO COMERCIAL DE AMBURANA E SUAS IMPLICAÇÕES NA PROLIFERAÇÃO CELULAR