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This research assessed the antioxidant activities and effects of some selected phenolic acids (ferulic, Caffeic, p-coumaric and chlorogenic acid) on enzymes of the purinergic signalling in isolated rat brain which include ATPdase, ecto- 51nucleotidase, phosphodiesterase and Na+/ K+ ATPase. Standard stock solutions (13mM) of the selected phenolics (Caffeic acid, ferulic acid, chlorogenic acid, p-coumaric acid) were prepared and several dilutions (0.05mM-10mM) were subsequently prepared; the ability of the phenolic acids to inhibit Fe2+ induced malondialdehyde (MDA) production in rat’s brain homogenates were assessed. Furthermore, the antioxidant activities of the phenolic acids as typified by the radicals (DPPH* and ABTS*) scavenging abilities were investigated. The results revealed that ferulic acid had the highest Na+/K+ -ATPase (IC50 =3.48 /ml) stimulatory activityas well as the highest ecto-5'-nucleotidase (IC50 =6.222 μg/ml) inhibitory activity while chlorogenic acid had the highest phosphodiesterase-51 (IC50 =21.03μg/ml) inhibitory activity and P-coumaric acid  had the highest inhibition of ATPDase (IC50 =17.56 μg/ml)  activity. Also, chlorogenic acid had the highest ABTS* and DPPH* scavenging abilities and also the strongest inhibition of Fe2+ induced MDA production in rat brain. However, this study revealed that the phenolic acids altered critical enzymes of the purinergic signaling and therefore suggests their possible neuromodulatory effect.

Modulatory effect of some selected phenolic acids on enzyme activities of purinergic signaling