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. The urgency of the problem of liver cirrhosis (LC) is caused by the in­ crease in morbidity, prevalence, life­threatening complications, disability and increasing mortality of able­bodied population. The aim of the study was to examine the effect of complex treatment with ademethionine, arginine glutamate and rosuvastatin on chang­ es in the haemostasis systemin patients with alcoholic liver cirrhosis (ALC) in combina­ tion with obesity. Research methods. The study included 105 patients diagnosed with ALC in combination with obesity. The assessment of the effectiveness of a three­month treatment regimen with ademethionine, arginine glutamate and rosuvastatin in obese patients with alcoholic liver cirrhosis (ALC) included indicators of synthetic liver func­ tion and hemostasis (total protein, albumin, fibrinogen, platelet count, factor Von Wil­ lebrand factor, activated partial thromboplastin time (APTT), thrombin time (TT), in­ ternational normalized ratio (INR), prothrombin index (PI), D-dimer, tissue plasminogen activator (tPA), 1 plasminogen activator (PAI-1), tPA/PAI-1 index, asymmetric dimethy­ larginine (ADMA)), as well as liver cirrhosis severity (Child-Pugh score) and 3-month MELD mortality score. Results. Decreased levels of total protein, albumin, fibrinogen, PI, platelet count and increased levels of Von Willebrand factor, prothrombin time (PT), APTT, TT, INR, D­dimer, tPA and PAI­1, ADMA were revealed. Such changes worsened with increasing liver cirrhosis decompensation and were accompanied by an increase in the Child-Pugh and MELD scores (P < 0.05). There was a more pronounced increase in levels of PAI-1 than tPA, that was accompanied by a decrease in tPA/PAI-1 index. A number of researchers indicate that an increase in PAI­1 levels can cause a hyperco­ agulable state, so its increase with a decrease in tPA/PAI-1 index in patients with ALC in combination with obesity indicates a risk of thrombogenic conditions. This is also evidenced by the increasing number of D-dimers. Therefore, the fibrinolytic/antifibrino­ lytic factors should be considered in the treatment of such patients to prevent LC com­ plications. Conclusions. The inclusion of ademethionine, arginine glutamate and rosu­ vastatin in the treatment regimen for 3 months improved the levels of total protein, albumin, fibrinogen, PI, platelet count, Von Willebrand factor, PT, APTT, TT, INR, D­ dimer, tPA and PAI­1, ADMA, which was accompanied by a decrease in Child­Pugh severity score and MELD 3­month mortality score.

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CHANGES IN THE HAEMOSTASIS SYSTEM UNDER THE INFLUENCE OF TREATMENT OF PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS IN COMBINATION WITH OBESITY USING ADEMETHIONINE, ARGININE GLUTAMATE AND ROSUVASTATIN