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Effect of naturally occurring sulphur-containing compounds such as diallyl sulphide (DAS), diallyl disulphide (DADS), and allyl methyl sulphide (AMS) on the inhibition of lung metastasis of B16F-10 melanoma cells was studied in C57BL/6 mice. Simultaneous administration of the compounds after tumor induction produced a significant reduction in tumor nodule formation (DAS 55%, DADS 90%, and AMS 54%). The effect was lower when the compounds were administered after tumor development, whereas prophylactic administration of the compounds did not have any effect on lung tumor nodule formation. Increased lung collagen hydroxyproline, serum sialic acid, and gamma glutamyl transpeptidase activity in the metastasized lungs of control animals was significantly reduced in the animals treated with the sulphur-containing compounds. Pathology of the lung tissue also correlated with the above findings. Our results are indicative of the antimetastatic activity of these sulphur-containing compounds.

Effect of Diallyl Sulphide, Diallyl Disulphide, and Allyl Methyl Sulphide on the Inhibition of Lung Metastasis of B16F-10 Melanoma Cells in Mice.