English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

BackgroundThe association of various addictions with oral squamous cell carcinoma (OSCC) has been well established. But it’s any possible link with metal toxicity has not been studied in the context of this carcinoma. AimTo correlate the variation in the effect of various addictions with arsenic toxicity in the development of OSCC in the study population. Settings and designIt is a case-control study. Ethical clearance was obtained from the institutional committee. A total of 104 oral malignant, 103 premalignant and 200 age and sex matched healthy individuals were selected for the study. The history of addictions of case and controls was collected from questionnaire. Methods and materialOn proper consent of cases & controls, the hair samples were collected for arsenic estimation by flow injection hydride generation atomic absorption spectrometry and the peripheral venous blood samples were processed for human leukocyte culture followed by Giemsa staining for the detection of chromosomal abnormality. Statistical analysis usedStudent t test, logistic regression by R software and correlation analysis by Graph Pad software. ResultsSignificant correlation was observed between arsenic toxicity & OSCC (p value = 2.18e-06 ***). Smoking tobacco (r value 0.5365) was more significant over chewing tobacco (r value 0.4804). 3% of malignant cases showed chromosomal break. ConclusionStatistically significant correlation among arsenic, addictions & OSCC in this study may indicate an associative role between the two factors. However, the study could not define any correlation with cytogenetic damage.

Is There any Effect of Addictions in Arsenic Induced Oral Carcinoma?