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ABS TRACT Objective: To evaluate vitamin D deficiency in patients with metabolic syndrome and to examine its effect on anxiety-depression. Material and Methods: Seventy one participants diagnosed with and without metabolic syndrome according to the International Diabetes Federation 2005 criteria were included into the study (35 participants in metabolic syndrome group, 36 participants in control group). Participants with rheumatological disease, fibromyalgia, anxiety-depression, history of orthopedic surgery and/or medication for any psychiatric illness were excluded from the study. The study was planned retrospectively. Demographic characteristics, waist and hip circumference measurement were examined. Blood triglyceride, HDL cholesterol, fasting plasma glucose, vitamin D levels, systolic and diastolic blood pressures and hospital anxiety-depression (HAD) scale were recorded retrospectively at the date when the HAD scale were applied. Results: Gender, age, height, weight, body mass index and hip circumference measurement were similar in both groups. Waist circumference measurement was significantly higher in the metabolic syndrome group compared to the control group (p=0.031). Triglyceride, fasting plasma glucose level, systolic and diastolic blood pressure were found to be significantly higher in the metabolic syndrome group compared to the control group. There was no significant difference in vitamin D level between two groups. While the anxiety score was found to be similar between two groups, the depression score was significantly higher in the metabolic syndrome group compared to the control group (respectively; p=0.917, p=0.008). There was no correlation between blood vitamin D level and waist circumference, hip circumference measurements, blood triglyceride, HDL cholesterol, fasting plasma glucose levels, anxiety and depression scores in the metabolic syndrome group. Conclusion: Independent of vitamin D deficiency, an increase in the level of depression was detected in participants with metabolic syndrome. It was thought that there was no relationship between depression, anxiety and vitamin D levels in patients with metabolic syndrome.

Evaluation of Vitamin D Deficiency in Patients with Metabolic Syndrome and its Effect on Anxiety-Depression