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raumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in young adults. As advanced intensive care facilities available, more patients can survive after severe brain injury, which increases the rates of disability and the risk of socio-economic burden.1 All neurological damage does not occur at the injury time after TBI, but secondary impact can occur hours and days after the injury and can affect mortality, morbidity and treatment response during rehabilitation process.2 Secondary injury can cause the autonomic dysfunction, electrolyte imbalance and disturbances of hormonal metabolism leading to systemic dysfunction, which can negatively affect rehabilitation process.3-5

Dysfunction of Hypothalamic-Pituitary Axis: A Complicating Condition for Rehabilitation in Patients with Traumatic Brain Injury