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Cell senescence is a naturally occurring phenomenon characterized by a loss of mitotic potential and changes in cell structure and physiology that include altered cell morphology, increased activity of senescence-associated beta-galactosidase (SABG), altered patterns of gene expression and protein synthesis, and changes in the secretory phenotype [1-4]. Although cell senescence is thought to have important adaptive purposes, such as tumor suppression [1,4,5], it can also disrupt the integrity and functioning of tissues containing senescent cells [1,2,4,5].

Inhibition of Retinal Pigment Epithelial Cell Senescence by Metformin: Implications for the Treatment of Macular Degeneration