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Chronic kidney disease (CKD), a disease characterized by tubulo-interstitial inflammation, tubular atrophy and interstitial fibrosis with progressive loss of renal function, has become a relatively common condition in dogs and cats. Due to the fact that renal transplantation is not yet a viable option in veterinary medicine, studies have been carried out to evaluate the possibility of treatment of CKD with mesenchymal stem cells (MSCs) due to the anti-inflammatory, anti-oxidant, anti-fibrotic and immunomodulatory responses that these cells possess. Eleven patients with CKD (6 dogs and 5 cats) were evaluated and submitted to therapy with halogen MSCs. All 5 cats and 4 out of the 6 dogs had a decrease in serum creatinine levels after cell transplantation, indicating that there was a significant decrease in creatinine in dogs (P = 0.0238). There was also a considerable decrease in the frequency of vomiting (P<0.05) and increase in the appetite (P<0.05) of the animals that received the cell therapy, according to the tutors' perception. These results suggest that

Avaliação da terapia com células-tronco mesenquimais halógenas em doença renal crônica de cães e gatos