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The inability of some species to produce porphyrin-like compounds induces these species to search for blood to fulfill their heme requirement. The biological cycle of very relevant parasites, such as Leishmania sp. and Trypanossoma sp., is directly related to the search for heme. The understanding of this process in a chemical and biochemical approach is a pre-requisite to obtaining advancements regarding hemoprotein structureactivity relationships as well as molecular aspects of various pathological/physiological mechanisms associated with parasitary and/or blood diseases, between others. The present work presents an overview of the chemical/biochemical properties of porphyrin, heme, heme proteins, and parasitary diseases caused by Trypanossomatidae. We believe that this kind of discussion can contribute significantly to improve the understanding of the structure-function relation of these complex diseases.

Heme Acquisition by trypanosomatids: Evaluation of the hemedependent behavior and its biochemical implications