English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives: Multi-drug resistance (MDR) remains one of the major obstacles to successful chemotherapy in patients with cancer. BRAF-activated non-coding RNA (BANCR) has been reported to be regulated in non-small cell lung cancer (NSCLC). In the present study, the researchers investigated the effects of ultrasound on BANCR expression, and its possible mechanisms were investigated in vitro and in vivo. Methods: The Adriamycin-resistance of A549/ADM cells and the transplantation tumor model of A549/ADM in nude mice were established. Real-time PCR was used to quantify BANCR expression in cells and in mice examined with or without ultrasound. P-gp and MRP protein expression were measured by western blot. The cell viability was detected by MTT assay. Results: ANCR expression was significantly elevated by ultrasound in A549/ADM cells and tumor tissue from xenograft mice. In in vitro experiments, P-gp and MRP levels were markedly reduced by ultrasound. When the cancer cells up-regulated BANCR by transfection of pCDNA-BANCR, P-gp and MRP levels were inhibited. In addition, the down-regulation of BANCR by si-BANCR transfection elevated their expression. Conclusion: Ultrasound reversed adriamycin-resistance in A549/ADM cells by regulating BANCR expression, and P-gp and MRP regulation were involved in this process.

Ultrasound reverses adriamycin-resistance in non-small cell lung cancer via positive regulation of BRAF-activated non-coding RNA (BANCR) expression