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Performance neuronal dimensions include the realization of attribute formulation in terms of folded molecules with a specifically targeted landscape of protein misfolding. Misfolding patterns of molecular structure perform proportional identity reformulation in terms of ongoing systems for re-appraisal of free energy levels with solute-solvent dimensions. The promotional re-creation for misfolding is integral to the parent attributes of folding and refolding that carry considerable reconstitution patterns of disease establishment and progression. Emergent patterns of aggregating dynamics perform the series of accumulated intermediate protein forms within the system profile determinations of consequential cooperative phenomena for protein molecular misfolding and accumulation within cells and tissues such as the central nervous system. 130 Japan Journal of Medicine 2018; 1(2): 130-133 . doi: xxx/jjm.106

Misfolded Protein Molecules as Added Dimensions of Generic Performance Dynamics of Neuronal Function and Dysfunction