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Two and more types of tumors rarely occur in the appendix, a constrained space of the human body. Weexperienced a rare co-occurrence of schwannoma and low-grade mucinous neoplasm (LAMN) in theappendix and obtained a lesson to scrutinize the radiological images in the follow-up period. A computertomography (CT) performed for surveillance of bile duct stone of a 68-year-old man incidentally detectedthe appendiceal tumor, which characteristics were not clear at that time, 1-year before admission becauseof epigastric pain due to acute cholecystitis. CT showed enlargement of tumor in the appendix, andlaparoscopic ileocecal resection and cholecystectomy were performed under the diagnosis of acutecholecystectomy and appendiceal tumor. Histopathological examination revealed two types of appendicealtumors, schwannoma and low-grade appendiceal neoplasm. To the best of our knowledge, co-occurrence ofschwannoma and LAMN has never been reported and this complicated our interpretation of clinical imagesduring the course. We report a clinical lesson in handling this rare combination of tumors in the appendixwith the relevant literature.

Co-Occurrence of Submucosal Schwannoma and Low-Grade Mucinous Neoplasm in the Appendix, a Clinical Conundrum : A Case Report