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The present study was conducted to test the use of the hemiparkinsonian rat, obtained by the unilateralinjection of 6-hydroxydopamine (6-OHDA) in the substantia nigra pars compacta (SNc), as a suitable modelfor the study of pain associated to Parkinson’s disease (PD). For this purpose, 14 days after unilateralinjection of saline or 6-OHDA, rats were assessed for behavioral function in the cylinder test, andapomorphine-induced circling test. Thereafter, at 21st day after injection, mechanical nociceptive thresholdwas compared between 6-OHD-lesioned and sham-operated animals using electronic von Frey test. Ourresults showed that injection of 6-OHDA in the SNc induced alterations of behavioral motor as ascertainedby predominant use of the ipsilateral forepaw in cylinder test and by the expression of contralateral turningsafter subcutaneous injection of apomorphine. The mechanical nociceptive threshold was significantlydecreased in 6-OHDA-lesioned rats compared to that of sham-operated rats (p &lt;0.05). This response wasreversed by apomorphine treatment. In conclusion, hemiparkinsonian rat, obtained by the unilateralinjection of the 6-OHDA in the SNc, can be used to investigate pain symptoms and central pain processingmechanisms related to PD.

Unilateral 6-Hydroxydopamine-Lesioned Rat as Relevant Model to Study the Pain Related to Parkinson’s Disease