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Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absenceof underlying causes. BMS patients can pose a therapeutic challenge to clinicians. Amitriptyline has been afirst-line treatment for BMS and is known to prolong corrected QT interval (QTc) in a dose dependentmanner. However, little is known about the QTc lengthening effect of amitriptyline at analgesic dosages.The objective of this study was to evaluate changes in QTc in female BMS patients treated withamitriptyline. We conducted a single-center retrospective observational study and evaluated 40 female BMSpatients. The QTc interval did not show statistically significant increase with amitriptyline (p=0.1502).However, the change in QTc of amitriptyline-responders was significantly longer than that of nonresponders (p=0.0142). The change in QTc may be a non-invasive maker of clinical responses toamitriptyline in female BMS patients.

An increase in corrected QT interval may indicate a good clinical response to amitriptyline in female patients with burning mouth syndrome