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Objective: The aim of the study was to assess the prognostic significance of pretreatment serum PSA level,immunohistochemical expression (labelling index, LI) of Ki-67, prostate-specific membrane antigen(PSMA), glucose-1 transporter (GLUT-1), vascular endothelial growth factor (VEGF), human telomerasereverse transcriptase (hTERT), as well as micro vessel density (MVD) for overall survival (OS), localrecurrence-free survival (LRFS), metastatic-free survival (MFS) and disease-free survival (DFS) in a groupof 130 prostate cancer (PCa) patients treated with radical prostatectomy (RP) between 2007 and 2011.Methods: In order to investigate the prognostic value of the analyzed variables in univariate andmultivariate Cox analysis, the patients were divided into two subgroups based on the marker cut-off pointsselected by the receiver operating characteristic curves.Results: There were 83 (63.8%) cases staged pT1-2 and 47 (36.1%) staged pT3-4. The majority of tumours(53.1%) were well-differentiated (grade group G1), 49 (37.7%) moderately differentiated (G2-3) and 12(9.2%) poorly differentiated (G4-5). In 85 patients (65.4%) the surgery was radical, 59 (45.4%) had positivesurgical margins (PSM), and in 23 (17.7%) seminal vesicle(s) involvement was diagnosed. Median followup was 79 (1-148) months, during which 55 (42.3%) men died, in 12 (9.2%) local relapse and in 13 (10%)distant metastases occurred. In multivariate Cox analysis, independent negative prognostic factors for OSwere: Ki-67LI &gt;6.7% (p=0.010), PSMALI ≤51.7% (p=0.009), hTERTLI ≤20.5% (p=0.004) and lack ofadjuvant treatment (AT) (p=0.013), while for MFS: seminal vesicle(s) involvement (p=0.007) and hTERTLI≤43.8% (p=0.011). However, non-radical surgery (p=0.007), PSM (p=0.005) and AT (p=0.037) werenegatively associated with DFS.Conclusion: Tumour biological markers are significant for OS and clinical parameters for DFS in PCapatients’ after RP.

clinical oncology and research

Significance of Tumour Biological Markers for Overall Survival and Clinical Parameters for Disease-Free Survival in Patients with Prostate Cancer after Radical Prostatectomy