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Ovarian neoplasms are among the most common in the female genital tract and often have delayeddiagnosis. Tumor progression involves signalling proteins called galectins. The aim of the present studywas to evaluate the immunohistochemical expression of galectins “1”, “3” and “9” in the ovarian surfaceepithelial neoplasia. A retrospective study involving 62 ovarian epithelial tumors (benign and non-benign)was performed with immunohistochemical polymer technique and antibodies against galectin “1”, “3” and“9”. Expression in epithelium and stroma was analysed semi-quantitatively. Fisher’s exact test wasperformed for statistical analysis. Galectin-“1” and “3” were strongly expressed in non-benign tumors ofthe epithelium. Non-benign neoplasms showed increased stromal expression of galectin-1 and increasedepithelial expression of galectin-“3”. The significant increase in expression of galectin-1 and -3 in theepithelium of non- benign ovarian neoplasms suggests the participation of these galectins in ovariancarcinogenesis. We observed increased stromal expression of galectin-“1” and epithelial expression ofgalectin-“3” in non-benign ovarian neoplasms. These findings contribute to knowledge about the role ofthese galectins in the growth and spread of ovarian cancer.

Comparative Immunohistochemical Study of Galectins 1, 3 and 9 in Ovarian Epithelial Neoplasms